Results of Endometrial Sampling in Patients with Abnormal Premenopausal Hemorrhages: Analysis of 1492 Cases

Abstract

OBJECTIVE: The aim of the study is the evaluation of histopathologic pattern in premenopausal patients subjected to endometrial sampling due to abnormal uterine hemorrhages. STUDY DESIGN: The results of 1492 premenopausal patients subjected to endometrial sampling due to abnormal uterine hemorrhages in Diyarbakır Maternity and Children Hospital between January 2013 and December 2013 have been evaluated retrospectively. Adolescents have been excluded from the study. RESULTS: The average age of the patients was 40.75±7.18 years and parity average was 5.01±2.87. 562 of the cases (37.7%) were from the 19-39 years age group while 930 of them (62.3%) were from the 40-51 years age group. The diagnoses were as follows: secretory endometrium for 547 of the cases (36.7%), proliferative endometrium for 377 of the cases (25.3%), endometrial polyp for 179 of the cases (12%), irregular proliferative endometrium for 137 of the cases (9.2%), simple endometrial hyperplasia for 93 of the cases (6.2%), endometritis for 81 of the cases (5.4%), insufficient material for 58 of the cases (3.9%), complex endometrial hyperplasia for 17 of the cases (1.1%) and endometrial adenocarcinoma for 3 of the cases (0.2%). CONCLUSION: In premenopausal cases, functional endometrial modifications (secretory and proliferative endometrium) are the most frequent observations. Endometrium cancer, endometrial polyp and precancer endometrial hyperplasia increase with age. High parity rates are supposed to decrease the risk of endometrium cancer.

Keywords

• Abnormal uterine hemorrhage, Premenopause, Histopathologic diagnosis