Synthesis of the glycerophospholipids with polymerizable groups for the stable nanoparticles formation.

Abstract

Synthesis of 1,2-di-(11,13-tetradecadienoyl)-sn-glycero-3-phosphocholine and 1,2-di- (2,4-hexadienoyl)-sn-glycero-3-phosphocholine, containing terminal polymerizable diene groups has been carried out. It is supposed that using of synthesized phosphorlipids mixtures followed by their polymerization will lead to formation of stable nanoparticles – bicelles, which will be capable to exist in a wide range of concentration of mixed components and resistant to organic solvents action.