Nature Communications (Nov 2022)
Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models
- Ke Song,
- Xinyan Yang,
- Geng An,
- Xinyu Xia,
- Jiexiang Zhao,
- Xiaoheng Xu,
- Cong Wan,
- Tianyuan Liu,
- Yi Zheng,
- Shaofang Ren,
- Mei Wang,
- Gang Chang,
- Shane J. F. Cronin,
- Josef M. Penninger,
- Tao Jing,
- Xianghong Ou,
- Shuan Rao,
- Zhaoting Liu,
- Xiao-Yang Zhao
Affiliations
- Ke Song
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Xinyan Yang
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Geng An
- Reproductive Medicine Center of The Third Affiliated Hospital of Guangzhou Medical University
- Xinyu Xia
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Jiexiang Zhao
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Xiaoheng Xu
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Cong Wan
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Tianyuan Liu
- Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University
- Yi Zheng
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Shaofang Ren
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Mei Wang
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Gang Chang
- Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Biochemistry and Molecular Biology, Shenzhen University Health Science Center
- Shane J. F. Cronin
- IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
- Josef M. Penninger
- IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
- Tao Jing
- Reproductive Medicine Center, Guangdong Second Provincial General Hospital
- Xianghong Ou
- Reproductive Medicine Center, Guangdong Second Provincial General Hospital
- Shuan Rao
- Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University
- Zhaoting Liu
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Xiao-Yang Zhao
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- DOI
- https://doi.org/10.1038/s41467-022-34990-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Type 2 diabetes often presents with reproductive disorders, including reduced male and female fertility. Here they show that diabetes disrupts the APLN signaling axis in the testes and that spermatogenesis can be restored through treatment with an APLN antagonist.
