Clinical Management Issues (Oct 2015)

Nilotinib therapy after resistance and intolerance to imatinib in CML patient with trisomy of the chromosome 8

  • Antonella Russo Rossi

DOI
https://doi.org/10.7175/cmi.v4i5S.1095
Journal volume & issue
Vol. 4, no. 5S
pp. 23 – 27

Abstract

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In this article is presented the case of a 30-year-old woman with chronic myeloid leukaemia (CML) treated with imatinib for 15 months, and then with nilotinib as second-line therapy. Two episodes of grade 3 neutropenia, the detection of the trisomy of chromosome 8 and the failed achievement of a major molecular response (MMolR) in 15 months led to the switch to nilotinib. With nilotinib the patient obtained the lack of the genetic anomaly in 3 months and a complete molecular response (CMolR) in 6 months, all confirmed at 9 months. No haematologic or extra-haematologic adverse events were detected with this second-line agent.

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