Acta Scientiarum. Health Sciences (Jul 2020)

Biopharmacotechnical and physical properties of solid pharmaceutical forms containing rutin commercially acquired in Juiz de Fora city, Brazil

  • Thiago Maurício de Souza Pinto,
  • Fabrini Luiz Alves Almeida,
  • Julianna Oliveira de Lucas Xavier,
  • Glauciemar Del-Vechio-Vieira,
  • Ana Lúcia Santos de Matos Araújo,
  • José de Jesus Ribeiro Gomes de Pinho,
  • Maria Silvana Alves,
  • Orlando Vieira de Sousa

DOI
https://doi.org/10.4025/actascihealthsci.v42i1.52212
Journal volume & issue
Vol. 42, no. 1

Abstract

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Rutin is a flavonoid used in clinical practice to treat capillary fragility and prevent bleeding due to its wide variety of pharmacological actions, including antioxidant, anti-inflammatory, anti-allergic, antiproliferative, and anticarcinogenic activities. In this study, the biopharmacotechnical and physical properties of film-coated tablets containing rutin marketed in drugstores were evaluated. Using samples from three batches called A, B and C, we determined the average weight, disintegration time, hardness, content and dissolution profile, and kinetics of the tablets. The samples demonstrated average weight of 457.45 ± 12.32 to 449.15 ± 8.95 mg; disintegration time, 30.17 ± 2.14 to 15.17 ± 2.14 min; hardness, 1.92 ± 0.55 to 1.69 ± 0.36 Kgf; and rutin content, 18.34 ± 1.21 to 15.66 ± 1.29 mg. After 90 min, the dissolution profile showed 52.65, 41.80, and 79.2% for A, B, and C, respectively. The results imply that the non-conformities of the tested products can significantly compromise the drug’s therapeutic efficacy.

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