Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling

Koto Kikuma; Xiling Li; Sarah Perry; Qiuling Li; Pragya Goel; Catherine Chen; Daniel Kim; Nicholas Stavropoulos; Dion Dickman

doi:10.1038/s41467-019-10992-6

Nature Communications (Jul 2019)

Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling

Koto Kikuma,
Xiling Li,
Sarah Perry,
Qiuling Li,
Pragya Goel,
Catherine Chen,
Daniel Kim,
Nicholas Stavropoulos,
Dion Dickman

Affiliations

Koto Kikuma: Department of Neurobiology, University of Southern California
Xiling Li: Department of Neurobiology, University of Southern California
Sarah Perry: Department of Neurobiology, University of Southern California
Qiuling Li: Neuroscience Institute, Department of Neuroscience and Physiology, NYU School of Medicine
Pragya Goel: Department of Neurobiology, University of Southern California
Catherine Chen: Department of Neurobiology, University of Southern California
Daniel Kim: Department of Neurobiology, University of Southern California
Nicholas Stavropoulos: Neuroscience Institute, Department of Neuroscience and Physiology, NYU School of Medicine
Dion Dickman: Department of Neurobiology, University of Southern California

DOI: https://doi.org/10.1038/s41467-019-10992-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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The authors use a forward genetic screen to discover postsynaptic factors required for homeostatic synaptic plasticity at the Drosophila neuromuscular junction. They identify insomniac and the ubiquitin ligase Cul3, genes involved in sleep regulation, to be necessary for retrograde homeostatic signalling at this synapse.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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