The Impact of Obesity on C1q/TNF-Related Protein-9 Expression and Endothelial Function following Acute High-Intensity Interval Exercise vs. Continuous Moderate-Intensity Exercise
Brandon G. Fico,
Ryan S. Garten,
Michael C. Zourdos,
Michael Whitehurst,
Peter J. Ferrandi,
Katelyn M. Dodge,
Gabriel S. Pena,
Alexandra A. Rodriguez,
Chun-Jung Huang
Affiliations
Brandon G. Fico
Department of Kinesiology, University of Wisconsin-Madison, Madison, WI 53706, USA
Ryan S. Garten
Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA
Michael C. Zourdos
Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA
Michael Whitehurst
Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA
Peter J. Ferrandi
College of Graduate Health Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
Katelyn M. Dodge
Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA
Gabriel S. Pena
Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
Alexandra A. Rodriguez
Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA
Chun-Jung Huang
Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA
C1q-TNF-related protein-9 (CTRP9) increases endothelial nitric oxide synthase and reduces vasoconstrictors. There is limited information regarding exercise-mediated CTRP9 in obesity. The purpose of this study was to compare high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CME) on the CTRP9 response and an indicator of endothelial function (FMD) in obese participants. Sixteen young male participants (9 obese and 7 normal-weight) participated in a counterbalanced and caloric equated experiment: HIIE (30 min, 4 intervals of 4 min at 80–90% of VO2 max with 3 min rest between intervals) and CME (38 min at 50–60% VO2 max). Serum CTRP9 and FMD were measured prior to, immediately following exercise, and 1 h and 2 h into recovery. CTRP9 was significantly increased immediately following acute HIIE and CME in both groups (p = 0.003). There was a greater CME-induced FMD response at 2 h into recovery in obese participants (p = 0.009). A positive correlation between CTRP9 and FMD percent change was observed in response to acute CME when combined with both obese and normal-weight participants (r = 0.589, p = 0.016). The novel results from this study provide a foundation for additional examination of the mechanisms of exercise-mediated CTRP9 on endothelial function in individuals with obesity.
