Oncology Reviews (Dec 2011)

Clinical and pathological implications of GSTM1 and GSTT1 gene deletions in sporadic breast cancer

  • Cassio Cardoso Filho,
  • Gustavo Lourenço,
  • Julia Yoriko Shinzato,
  • Luiz Carlos Zeferino,
  • Fernando Ferreira Costa,
  • Carmen Silvia Passos Lima,
  • Maria Salete Costa Gurgel

Journal volume & issue
Vol. 2, no. 1
pp. 36 – 43

Abstract

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There is a lack of consensus about the influence of GST M1/T1 gene deletions (DEL) on sporadic breast cancer (SBC). To evaluate the occurrence of DEL in 177 SBC cases and in 169 controls, and compare clinical and biological characteristics. A lower frequency of GSTM1 DEL was observed in mulatto women, OR=0.48 (0.24–0.98). The risk of nuclear grade 3 tumors (GN3) was lower in patients with GSTT1 DEL, OR=0.37 (0.15–0.90). DEL of at least one gene (ALOG) was associated with women who had not breastfed, OR=0.41 (0.19–0.88), and with negative hormone receptor, HR–, ORadj=2.25 (1.03–4.90). Both genes deleted (BGD) was associated with non-classic invasive ductal carcinoma (NCDC), ORadj=12.09 (1.03–142.03). Mulatto women with SBC had a lower frequency of GSTM1 DEL, while tumors differentiated were related to GSTT1 DEL. HRtumors were related with DEL ALOG, and the BGD was associated with a greater risk of NCDC.

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