Journal of Hebei University of Science and Technology (Dec 2021)
Study on albendazole dispersible tablets based on solubilization effect
Abstract
In order to improve the dissolution properties of albendazole and solve the problem of dysphagia caused by conventional tablets in patients,the prescription and preparation process of albendazole dispersible tablets were explored based on the solubilization effect.The effects of adding surfactants and preparing inclusion compounds on dissolution were investigated to screen the method of increasing the solubility of albendazole.Adhesives,disintegrants,solubilizers,and lubricants were screened by single factor experiment with compressibility,hardness,disintegrating time,and dissolution as indicators.The formulation and preparation process of albendazole dispersible tablets were optimized by orthogonal test.Three batches of albendazole dispersible tablets were prepared by the optimal prescription and process,the qualities were evaluated in vitro,and the content and dissolution were measured by UV-spectrophotometry.The results show that adding mixed surfactants of sodium dodecyl sulfate(SDS) and Tween 80 can assist dissolution of albendazole in water.The optimal prescription is as follows:3% of SDS,16% of PVPP (with an internal and external ratio of 1∶1),3% of Tween 80,3% of HPMC and 1% of Magnesium Stearate.The albendazole dispersible tablets were prepared with wet granulation.Different batches of albendazole dispersible tablets completely disintegrated within 122 s,the accumulated dissolution of albendazole dispersible tablets within 45 minutes was more than 80%,which met the requirements of Pharmacopoeia of the People's Republic of China(2020).The formulation of albendazole dispersible tablets is reasonable,the preparation process is feasible and the quality is good in vitro,which provides research ideas and a theoretical basis for improving the bioavailability of oral dosage forms of biopharmaceutical classification system (BCS) class Ⅱ compounds.
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