Nature Communications (Jan 2017)

Whole-brain 3D mapping of human neural transplant innervation

  • Jonas Doerr,
  • Martin Karl Schwarz,
  • Dirk Wiedermann,
  • Anke Leinhaas,
  • Alina Jakobs,
  • Florian Schloen,
  • Inna Schwarz,
  • Michael Diedenhofen,
  • Nils Christian Braun,
  • Philipp Koch,
  • Daniel A. Peterson,
  • Ulrich Kubitscheck,
  • Mathias Hoehn,
  • Oliver Brüstle

DOI
https://doi.org/10.1038/ncomms14162
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 7

Abstract

Read online

Transplantation of cells into the central nervous system has developed into a major avenue for replacing neurons lost to neurodegenerative disease. Here the authors develop an approach combining viral-based transynaptic tracing labeling and whole brain imaging to trace synaptic innervation of human neurons transplanted into a mouse background.