Data for the effect of histone deacetylase inhibitors on voltage- and ligand-gated ion channel gene expression in neurogenic induced-human adipose tissue-derived mesenchymal stem cells

Abstract

This data article contains descriptive and experimental data on ion channel gene expressions following the histone deacetylase (HDAC) inhibitor treatment of neural induced human adipose tissue-derived mesenchymal stem cells (NI-hADSCs). Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. The expression of the ion channel marker genes, such as SCN5A, KCNA4, and CACNA1G, was highly increased following treatment with the HDAC inhibitors; however, the expression of others was either decreased or unchanged. For further details and experimental findings please refer to the research article by Jang and Jeong. Histone deacetylase inhibition-mediated neuronal differentiation via the Wnt signaling pathway in human adipose tissue-derived mesenchymal stem cells (Jang and Jeong, 2018) [1]. Keywords: Histone deacetylase inhibitors, Stem cells, Cell differentiation, Ion channels, Neurofilament-L