Communications Biology (Sep 2022)

The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3

  • Simona Notova,
  • François Bonnardel ,
  • Francesca Rosato,
  • Lina Siukstaite,
  • Jessica Schwaiger,
  • Jia Hui Lim,
  • Nicolai Bovin,
  • Annabelle Varrot,
  • Yu Ogawa,
  • Winfried Römer,
  • Frédérique Lisacek,
  • Anne Imberty

DOI
https://doi.org/10.1038/s42003-022-03869-w
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 17

Abstract

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A curated lectin database, structural characterization, and in vitro assays show that choanoflagellate lectin SaroL-1 binds to cancer-related α-galactosylated epitopes and can be toxic to cancer cells through a carbohydrate-dependent pore-formation mechanism.