The effect of lipid metabolism on age-associated cognitive decline: Lessons learned from model organisms and human

Abstract

Lipids are required as integral building blocks of cells to support cellular structures and functions. The intricate mechanisms underpinning lipid homeostasis are essential for the health and maintenance of the central nervous system. Here we summarize the recent advances in dissecting the effect of lipid metabolism on cognitive function and its age-associated decline by reviewing relevant studies ranging from invertebrate model organisms to mammals including human.

Keywords

• Lipid metabolism
• Age-associated cognitive decline
• Model organisms
• Human