Radiology Case Reports (Nov 2023)

Granulomatous mastitis with erythema nodosum: A breast cancer mimicking entity

  • Karina A. Pesce, MD, PhD,
  • Karen L. Caro Peralta, MD,
  • Maria Jose Chico, MD,
  • Alejandra Wernicke, MD,
  • Fernando Binder, MD, MPH

Journal volume & issue
Vol. 18, no. 11
pp. 3809 – 3814

Abstract

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We present the case of a 42-year-old Hispanic patient who consulted with a left breast mass that showed clinical and imaging signs of breast cancer. During preprocedural examination before needle biopsy, the patient was found to have bilateral, purplish-brown skin lesions on her lower legs, suggestive of erythema nodosum. This clinical finding raised the diagnostic suspicion of granulomatous mastitis, which was later confirmed by histopathology. Granulomatous mastitis is a rare, nonmalignant entity that should be considered in patients of childbearing age who present with a breast mass. The coexistence with erythema nodosum contributes to the clinical suspicion of granulomatous mastitis; the mechanism of this association and the optimal treatment approach remain unknown.

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