A LDH‐Derived Metal Sulfide Nanosheet‐Functionalized Bioactive Glass Scaffold for Vascularized Osteogenesis and Periprosthetic Infection Prevention/Treatment

Yixin Bian; Tingting Hu; Kexin Zhao; Xuejie Cai; Mengyang Li; Chaoliang Tan; Ruizheng Liang; Xisheng Weng

doi:10.1002/advs.202403009

Advanced Science (Oct 2024)

A LDH‐Derived Metal Sulfide Nanosheet‐Functionalized Bioactive Glass Scaffold for Vascularized Osteogenesis and Periprosthetic Infection Prevention/Treatment

Yixin Bian,
Tingting Hu,
Kexin Zhao,
Xuejie Cai,
Mengyang Li,
Chaoliang Tan,
Ruizheng Liang,
Xisheng Weng

Affiliations

Yixin Bian: Department of Orthopedic Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 P. R. China
Tingting Hu: Department Electrical and Electronic Engineering The University of Hong Kong Pokfulam Road Hong Kong, SAR 999077 P. R. China
Kexin Zhao: State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China
Xuejie Cai: Department of Orthopedic Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 P. R. China
Mengyang Li: State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China
Chaoliang Tan: Department Electrical and Electronic Engineering The University of Hong Kong Pokfulam Road Hong Kong, SAR 999077 P. R. China
Ruizheng Liang: State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China
Xisheng Weng: Department of Orthopedic Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 P. R. China

DOI: https://doi.org/10.1002/advs.202403009
Journal volume & issue: Vol. 11, no. 39
pp. n/a – n/a

Abstract

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Abstract Periprosthetic infection and prosthetic loosing stand out as prevalent yet formidable complications following orthopedic implant surgeries. Synchronously addressing the two complications is long‐time challenging. Herein, a bioactive glass scaffold (BGS) functionalized with MgCuFe‐layered double hydroxide (LDH)‐derived sulfide nanosheets (BGS/MCFS) is developed for vascularized osteogenesis and periprosthetic infection prevention/treatment. Apart from the antibacterial cations inhibiting bacterial energy and material metabolism, the exceptional near‐infrared‐II (NIR‐II) photothermal performance empowers BGS/MCFS to eliminate periprosthetic infections, outperforming previously reported functionalized BGS. The rough surface topography and the presence of multi‐bioactive metal ions bestow BGS/MCFS with exceptional osteogenic and angiogenic properties, with 8.5‐fold and 2.3‐fold enhancement in bone mass and neovascularization compared with BGS. Transcriptome sequencing highlights the involvement of the TGF‐β signaling pathway in these processes, while single‐cell sequencing reveals a significant increase in osteoblasts and endothelial cells around BGS/MCFS compared to BGS.

Published in Advanced Science

ISSN: 2198-3844 (Online)
Publisher: Wiley
Country of publisher: Germany
LCC subjects: Science
Website: https://onlinelibrary.wiley.com/journal/21983844

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