Nature Communications (Feb 2018)

Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways

  • Maciej Czerkies,
  • Zbigniew Korwek,
  • Wiktor Prus,
  • Marek Kochańczyk,
  • Joanna Jaruszewicz-Błońska,
  • Karolina Tudelska,
  • Sławomir Błoński,
  • Marek Kimmel,
  • Allan R. Brasier,
  • Tomasz Lipniacki

DOI
https://doi.org/10.1038/s41467-017-02640-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Innate immunity combines intra- and intercellular signalling to develop responses that limit pathogen spread. Here the authors analyse feedback and feedforward loops connecting IRF3, NF-κB and STAT pathways, and suggest they allow coordinating cell fate decisions in cellular populations in response to the virus-mimicking agent poly(I:C).