Nature Communications (Aug 2018)

NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer

  • Andrew T. Ludlow,
  • Mandy Sze Wong,
  • Jerome D. Robin,
  • Kimberly Batten,
  • Laura Yuan,
  • Tsung-Po Lai,
  • Nicole Dahlson,
  • Lu Zhang,
  • Ilgen Mender,
  • Enzo Tedone,
  • Mohammed E. Sayed,
  • Woodring E. Wright,
  • Jerry W. Shay

DOI
https://doi.org/10.1038/s41467-018-05582-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Splicing of the telomerase transcript, hTERT, can be altered in cancer cells. Here the authors report NOVA1, as a splicing regulator that directly interacts with hTERT pre-mRNA enhancing the number of full-length transcripts and thus telomerase activity in lung cancer cells.