Communications Biology (Jan 2023)
Structural basis underlying the synergism of NADase and SLO during group A Streptococcus infection
- Wei-Jiun Tsai,
- Yi-Hsin Lai,
- Yong-An Shi,
- Michal Hammel,
- Anthony P. Duff,
- Andrew E. Whitten,
- Karyn L. Wilde,
- Chun-Ming Wu,
- Robert Knott,
- U-Ser Jeng,
- Chia-Yu Kang,
- Chih-Yu Hsu,
- Jian-Li Wu,
- Pei-Jane Tsai,
- Chuan Chiang-Ni,
- Jiunn-Jong Wu,
- Yee-Shin Lin,
- Ching-Chuan Liu,
- Toshiya Senda,
- Shuying Wang
Affiliations
- Wei-Jiun Tsai
- Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University
- Yi-Hsin Lai
- Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University
- Yong-An Shi
- Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University
- Michal Hammel
- Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory
- Anthony P. Duff
- Australian Nuclear Science and Technology Organisation
- Andrew E. Whitten
- Australian Nuclear Science and Technology Organisation
- Karyn L. Wilde
- Australian Nuclear Science and Technology Organisation
- Chun-Ming Wu
- National Synchrotron Radiation Research Center, Hsinchu Science Park
- Robert Knott
- Australian Nuclear Science and Technology Organisation
- U-Ser Jeng
- National Synchrotron Radiation Research Center, Hsinchu Science Park
- Chia-Yu Kang
- Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University
- Chih-Yu Hsu
- Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Medical College
- Jian-Li Wu
- Institute of Biological Chemistry, Academia Sinica
- Pei-Jane Tsai
- Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University
- Chuan Chiang-Ni
- Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University
- Jiunn-Jong Wu
- Department of Medical Laboratory Science and Biotechnology, Asia University
- Yee-Shin Lin
- Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University
- Ching-Chuan Liu
- Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University
- Toshiya Senda
- Structural Biology Research Center, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK)
- Shuying Wang
- Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University
- DOI
- https://doi.org/10.1038/s42003-023-04502-0
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 12
Abstract
Structural and mutational analyses reveal interactions between NAD+-glycohydrolase and Streptolysin O critical for Group A Streptococcus virulence, validated in a murine infection model.
