Immunological and Haematological Relevance of Helminths and <i>Mycobacterium tuberculosis</i> Complex Coinfection among Newly Diagnosed Pulmonary Tuberculosis Patients from Bobo-Dioulasso, Burkina Faso
Diakourga Arthur Djibougou,
Gloria Ivy Mensah,
Achille Kaboré,
Inoussa Toé,
Leon Tinnoga Sawadogo,
Palpouguini Felix Lompo,
Amariane M. M. Kone,
Hervé Hien,
Clement Ziemlé Meda,
Adjima Combary,
Bassirou Bonfoh,
Kennedy Kwasi Addo,
Adrien Marie-Gaston Belem,
Roch Konbobr Dabiré,
Jonathan Hoffmann,
Matthieu Perreau,
Potiandi Serge Diagbouga
Affiliations
Diakourga Arthur Djibougou
Doctoral School of Natural Sciences and Agronomy, Université Nazi BONI, Bobo-Dioulasso 1091, Burkina Faso
Gloria Ivy Mensah
Department of Bacteriology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra 00233, Ghana
Achille Kaboré
Infectious Disease and Health Systems (IDHS), FHI 360, Washington, DC 20037, USA
Inoussa Toé
Doctoral School of Natural Sciences and Agronomy, Université Nazi BONI, Bobo-Dioulasso 1091, Burkina Faso
Leon Tinnoga Sawadogo
Doctoral School of Natural Sciences and Agronomy, Université Nazi BONI, Bobo-Dioulasso 1091, Burkina Faso
Palpouguini Felix Lompo
Etudes Formation et Recherches Développement en Santé (EFORDS), Ouagadougou 10 P.O. Box 13064, Burkina Faso
Amariane M. M. Kone
Infectious Diseases Program, Centre MURAZ, Institut National de Santé Publique, Bobo-Dioulasso 1091, Burkina Faso
Hervé Hien
Infectious Diseases Program, Centre MURAZ, Institut National de Santé Publique, Bobo-Dioulasso 1091, Burkina Faso
Clement Ziemlé Meda
Doctoral School of Natural Sciences and Agronomy, Université Nazi BONI, Bobo-Dioulasso 1091, Burkina Faso
Adjima Combary
National Tuberculosis Programme, Ministry of Health and Public Hygiene, Ouagadougou 01 P.O. Box 690, Burkina Faso
Bassirou Bonfoh
Centre Suisse de Recherches Scientifique de Côte d’Ivoire, Adiopodoumé 01 P.O. Box 1303, Côte d’Ivoire
Kennedy Kwasi Addo
Department of Bacteriology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra 00233, Ghana
Adrien Marie-Gaston Belem
Doctoral School of Natural Sciences and Agronomy, Université Nazi BONI, Bobo-Dioulasso 1091, Burkina Faso
Roch Konbobr Dabiré
Infectious Diseases Program, Centre MURAZ, Institut National de Santé Publique, Bobo-Dioulasso 1091, Burkina Faso
Jonathan Hoffmann
Département Médical et Scientifique, Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France
Matthieu Perreau
Faculty of Biology and Medicine, Université de Lausanne, 1010 Lausanne, Switzerland
Potiandi Serge Diagbouga
Institut de Recherche en Sciences de la Santé, CNRST, Bobo-Dioulasso 545, Burkina Faso
The effect of helminthiasis on host immunity is a neglected area of research, particularly in tuberculosis (TB) infection. This study aimed to evaluate the effect of helminthiasis on immunological and haematological parameters in newly diagnosed TB patients in Bobo-Dioulasso. After all biological analyses, we formed three subpopulations: group 1 (n = 82), as control, were participants without helminthic or Mycobacterium tuberculosis complex infection (Mtb−/Helm−), group 2 (n = 73) were TB patients without helminthic infection (Mtb+/Helm−), and group 3 (n = 22) were TB patients with helminthic infection (Mtb+/Helm+). The proportion of helminth coinfection was 23.16% (22/95) in TB patients, and Schistosoma mansoni infection was found in 77.3% (17/22) cases of helminthiasis observed in this study. A low CD4 T cell count and a low CD4:CD8 ratio were significantly associated with concomitant infection with helminths and the Mtb complex (Mtb+/Helm+) compared to the other groups (p p > 0.05). Lymphopenia, monocytosis, thrombocytosis, and hypochromic microcytic anaemia were the haematological defects observed in the Mtb+/Helm+ and Mtb+/Helm− patients. Exploring these types of immune–haematological biomarkers would be a valuable aid in diagnosing and a better follow-up and monitoring of the tuberculosis–helminthiasis coinfection.
