Dynamics of distribution of lithium in different tissues after oral administration of lithium citrate in rats

Abstract

Concentration time curves for whole blood and tissue homogenates of 11 different bio-substrates (brain, frontal lobe, heart, aorta, lungs, liver, kidneys, spleen, adrenal capsules, femur, urine) were obtained for lithium citrate at a dose of 1 000 mg/kg. In the course of a non-compartmental analysis of the concentrations dynamics in the whole blood the following values of the pharmacokinetic parameters of lithium citrate were obtained: Cmax = 54,1 mcg/l, Tmax = 1,50 h, Clast = 33,7 mcg/l, AUCt = 1776 mcg/l х h, MRTt = 22,7 h, Lz = 0,004 1/h, T1/2 = 146 h, CL = 0,014 l/h, Vd = 3,0. Lithium concentrations in the whole blood and in the brain frontal lobe were stable for at least 40...50 hours after overcoming the peak concentration. Multi-compartmental pharmacokinetic analysis showed that the stabilization of the lithium levels in the blood and in the brain is maintained due to the special lithium “depot” that includes brain, aorta, kidneys and femur.

Keywords

• цитрат лития
• бескамерная модель
• многокамерное моделирование
• фармакокинетика
• биосубстраты
• lithium citrate
• non-compartmental model
• multi-compartmental modeling
• pharmacokinetics
• bio-substrates