Journal of Clinical Medicine (Jan 2020)
Characterization of Patients with Pulmonary Arterial Hypertension: Data from the Polish Registry of Pulmonary Hypertension (BNP-PL)
- Grzegorz Kopeć,
- Marcin Kurzyna,
- Ewa Mroczek,
- Łukasz Chrzanowski,
- Tatiana Mularek-Kubzdela,
- Ilona Skoczylas,
- Beata Kuśmierczyk,
- Piotr Pruszczyk,
- Piotr Błaszczak,
- Ewa Lewicka,
- Danuta Karasek,
- Katarzyna Mizia-Stec,
- Michał Tomaszewski,
- Wojciech Jacheć,
- Katarzyna Ptaszyńska-Kopczyńska,
- Małgorzata Peregud-Pogorzelska,
- Anna Doboszyńska,
- Agnieszka Pawlak,
- Zbigniew Gąsior,
- Wiesława Zabłocka,
- Robert Ryczek,
- Katarzyna Widejko-Pietkiewicz,
- Marcin Waligóra,
- Szymon Darocha,
- Michał Furdal,
- Michał Ciurzyński,
- Jarosław D. Kasprzak,
- Marek Grabka,
- Karol Kamiński,
- Piotr Hoffman,
- Piotr Podolec,
- Adam Torbicki
Affiliations
- Grzegorz Kopeć
- Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital in Krakow, Ul. Prądnicka 80, 31-202 Krakow, Poland
- Marcin Kurzyna
- Department of Pulmonary Hypertension, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, 05-400 Otwock, Poland
- Ewa Mroczek
- Department of Cardiology Provincial Specialist Hospital Research and Development Center, 51-124 Wrocław, Poland
- Łukasz Chrzanowski
- Cardiology Department, Medical University of Lodz, 91-347 Lodz, Poland
- Tatiana Mularek-Kubzdela
- Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznan, Poland
- Ilona Skoczylas
- 3rd Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Katowice, Poland
- Beata Kuśmierczyk
- Department of Congenital Heart Disease Institute of Cardiology, 04-628 Warsaw, Poland
- Piotr Pruszczyk
- Department of Internal Medicine and Cardiology, Medical University of Warsaw, 02-005 Warsaw, Poland
- Piotr Błaszczak
- Department of Cardiology, Cardinal Wyszynski Hospital, 20-718 Lublin, Poland
- Ewa Lewicka
- Department of Cardiology and Electrotherapy Medical University of Gdansk, 80-211 Gdansk, Poland
- Danuta Karasek
- 2nd Department of Cardiology, Faculty of Health Sciences, Collegium Medicum, Nicolaus Copernicus University, 85-168 Bydgoszcz, Poland
- Katarzyna Mizia-Stec
- I Katedra i Klinika Kardiologii, Wydział Lekarski w Katowicach, Śląski Uniwersytety Medyczny w Katowicach, 40-635 Katowice, Poland
- Michał Tomaszewski
- Department of Cardiology, Medical University of Lublin, 20-090 Lublin, Poland
- Wojciech Jacheć
- 2nd Department of Cardiology, School of Medicine with Dentistry Division in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland
- Katarzyna Ptaszyńska-Kopczyńska
- Department of Cardiology, Medical University of Bialystok, 15-276 Bialystok, Poland
- Małgorzata Peregud-Pogorzelska
- Department of Cardiology, Pomeranian Medical University, Szczecin, 70-111 Szczecin, Poland
- Anna Doboszyńska
- Pulmonary Department, University of Warmia and Mazury, 10-357 Olsztyn, Poland
- Agnieszka Pawlak
- Department of Invasive Cardiology, Polish Academy of Sciences, Mossakowski Medical Research Centre, Central Clinical Hospital of the Ministry of Interior, 02-507 Warsaw, Poland
- Zbigniew Gąsior
- Department of Cardiology, School of Health Sciences, Medical University of Cardiology in Katowice, 40-635 Katowice, Poland
- Wiesława Zabłocka
- Oddział Kardiologii i Kardiologii Inwazyjnej, Oddział Intensywnego Nadzoru Kardiologicznego, Samodzielny Publiczny Wojewódzki Szpital Zespolony w Szczecinie, 71-455 Szczecin, Poland
- Robert Ryczek
- Department of Cardiology and Internal Medicine, Military Institute of Medicine in Warsaw, 04-141 Warsaw, Poland
- Katarzyna Widejko-Pietkiewicz
- Department of Cardiology, Copper Health Center, 59-300 Lubin, Poland
- Marcin Waligóra
- Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital in Krakow, Ul. Prądnicka 80, 31-202 Krakow, Poland
- Szymon Darocha
- Department of Pulmonary Hypertension, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, 05-400 Otwock, Poland
- Michał Furdal
- Department of Cardiology Provincial Specialist Hospital Research and Development Center, 51-124 Wrocław, Poland
- Michał Ciurzyński
- Department of Internal Medicine and Cardiology, Medical University of Warsaw, 02-005 Warsaw, Poland
- Jarosław D. Kasprzak
- Cardiology Department, Medical University of Lodz, 91-347 Lodz, Poland
- Marek Grabka
- I Katedra i Klinika Kardiologii, Wydział Lekarski w Katowicach, Śląski Uniwersytety Medyczny w Katowicach, 40-635 Katowice, Poland
- Karol Kamiński
- Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, 15-269 Bialystok, Poland
- Piotr Hoffman
- Department of Congenital Heart Disease Institute of Cardiology, 04-628 Warsaw, Poland
- Piotr Podolec
- Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital in Krakow, Ul. Prądnicka 80, 31-202 Krakow, Poland
- Adam Torbicki
- Department of Pulmonary Hypertension, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, 05-400 Otwock, Poland
- DOI
- https://doi.org/10.3390/jcm9010173
- Journal volume & issue
-
Vol. 9,
no. 1
p. 173
Abstract
Current knowledge of pulmonary arterial hypertension (PAH) epidemiology is based mainly on data from Western populations, and therefore we aimed to characterize a large group of Caucasian PAH adults of Central-Eastern European origin. We analyzed data of incident and prevalent PAH adults enrolled in a prospective national registry involving all Polish PAH centers. The estimated prevalence and annual incidence of PAH were 30.8/mln adults and 5.2/mln adults, respectively and they were the highest in females ≥65 years old. The most frequent type of PAH was idiopathic (n = 444; 46%) followed by PAH associated with congenital heart diseases (CHD-PAH, n = 356; 36.7%), and PAH associated with connective tissue disease (CTD-PAH, n = 132; 13.6%). At enrollment, most incident cases (71.9%) were at intermediate mortality risk and the prevalent cases had most of their risk factors in the intermediate or high risk range. The use of triple combination therapy was rare (4.7%). A high prevalence of PAH among older population confirms the changing demographics of PAH found in the Western countries. In contrast, we found: a female predominance across all age groups, a high proportion of patients with CHD-PAH as compared to patients with CTD-PAH and a low use of triple combination therapy.
Keywords