Successful outcome of second allogeneic bone marrow transplantation for blastic plasmacytoid dendritic cell neoplasm with MYC locus rearrangement

Takeharu Kato; Hidehiro Itonaga; Jun Taguchi; Junya Makiyama; Machiko Fujioka; Masataka Taguchi; Makiko Horai; Yasushi Sawayama; Daisuke Niino; Yoshitaka Imaizumi; Tomoko Hata; Shinichiro Yoshida; Kana Sakamoto; Kengo Takeuchi; Koichi Ohshima; Yasushi Miyazaki

Leukemia Research Reports (Jan 2019)

Successful outcome of second allogeneic bone marrow transplantation for blastic plasmacytoid dendritic cell neoplasm with MYC locus rearrangement

Takeharu Kato,
Hidehiro Itonaga,
Jun Taguchi,
Junya Makiyama,
Machiko Fujioka,
Masataka Taguchi,
Makiko Horai,
Yasushi Sawayama,
Daisuke Niino,
Yoshitaka Imaizumi,
Tomoko Hata,
Shinichiro Yoshida,
Kana Sakamoto,
Kengo Takeuchi,
Koichi Ohshima,
Yasushi Miyazaki

Affiliations

Takeharu Kato: Department of Hematology, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan
Hidehiro Itonaga: Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan; Corresponding author.
Jun Taguchi: Department of Hematology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan
Junya Makiyama: Department of Hematology, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan; Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Machiko Fujioka: Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
Masataka Taguchi: Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
Makiko Horai: Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
Yasushi Sawayama: Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
Daisuke Niino: Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan
Yoshitaka Imaizumi: Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
Tomoko Hata: Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
Shinichiro Yoshida: Department of Hematology, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan
Kana Sakamoto: Pathology Project for Molecular Targets, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan; Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
Kengo Takeuchi: Pathology Project for Molecular Targets, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan; Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
Koichi Ohshima: Department of Pathology, School of Medicine, Kurume University, Fukuoka, Japan
Yasushi Miyazaki: Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan; Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan

Journal volume & issue: Vol. 11
pp. 31 – 33

Abstract

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A 62-year-old male was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN) with a MYC rearrangement. Four months after the first unrelated bone marrow transplantation (BMT), he developed the relapsed BPDCN. After the achievement of partial remission following re-induction therapy, he underwent a second BMT from another unrelated donor, and experienced complete remission with grade II acute graft-versus-host disease and moderate chronic graft-versus-host disease. He remains alive in complete remission more than 71 months after the second BMT. These results suggested that donor change at the second transplantation may represent a considerable therapeutic option for patients with relapsed BPDCN. Keywords: Blastic plasmacytoid dendritic cell neoplasm, Allogeneic hematopoietic stem cell transplantation, Donor change, MYC rearrangement

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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