Comprehensive assessment of cardiovascular complications in a patient with type 1 diabetes mellitus, chronic kidney disease and diabetic neuroosteoarthropathy

Abstract

The paper presents a clinical case of the patient with long-term poor control of type 1 diabetes mellitus, chronic kidney disease (CKD) and diabetic neurоosteoarthropathy. The characteristics of interest in the clinical case are CKD complications associated with mineral and bone metabolism disorders. Clinical consequences of vascular calcification due to secondary hyperparathyroidism, autonomic and peripheral neuropathy have resulted in cardiovascular complications. We discuss the diagnostic challenges of vascular calcification, as well as the interpretation of diagnostic methods in lower limb arterial disease, and provide evidence for the advantages of alternative treatment of secondary hyperparathyroidism with a selective activator of vitamin D receptors. The important role of CKD in the development of metabolic, structural and hemodynamic disorders in patients with type 1 diabetes mellitus is emphasized.

Keywords

• diabetes mellitus
• chronic kidney disease
• secondary hyperparathyroidism
• diabetic neuroosteoarthropathy