Bullous pemphigoid. Сlinic, Diagnosis and Treatment

Abstract

The article describes modern views on the predisposing factors, features, immunological changes and link with the histocompatibility antigens HLA, the role of circulating autoantibodies, cytokines, chemokines, matrix metalloproteinases and BP180 (BPAg2) и BP230 (BPAg1), those role in the pathogenesis of the bullous pemphigoid and their correlation with the activity of pathological process in patients with bullous pemphigoid. Described experimental model of the disease in animals, modern medications and methods of treatment of this disease.

Keywords

• bullous pemphigoid
• immunogenetic predisposition in the hla system
• circulating autoantibodies
• cytokines
• chemokines
• matrix metalloproteinases
• antigens bp180 and bp230