Immunogenicity and Immune Memory after a Pneumococcal Polysaccharide Vaccine Booster in a High-Risk Population Primed with 10-Valent or 13-Valent Pneumococcal Conjugate Vaccine: A Randomized Controlled Trial in Papua New Guinean Children
Anita H. J. van den Biggelaar,
William S. Pomat,
Geraldine Masiria,
Sandra Wana,
Birunu Nivio,
Jacinta Francis,
Rebecca Ford,
Megan Passey,
Lea-Ann Kirkham,
Peter Jacoby,
Deborah Lehmann,
Peter Richmond,
the 10v13v PCV Trial Team
Affiliations
Anita H. J. van den Biggelaar
Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA 6009, Australia
William S. Pomat
Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea
Geraldine Masiria
Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea
Sandra Wana
Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea
Birunu Nivio
Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea
Jacinta Francis
Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea
Rebecca Ford
Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea
Megan Passey
School of Public Health, University Centre for Rural Health (USRH), The University of Sydney, Lismore, NSW 2480, Australia
Lea-Ann Kirkham
Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA 6009, Australia
Peter Jacoby
Centre for Biostatistics, Telethon Kids Institute, Nedlands, WA 6009, Australia
Deborah Lehmann
Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA 6009, Australia
Peter Richmond
Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA 6009, Australia
We investigated the immunogenicity, seroprotection rates and persistence of immune memory in young children at high risk of pneumococcal disease in Papua New Guinea (PNG). Children were primed with 10-valent (PCV10) or 13-valent pneumococcal conjugate vaccines (PCV13) at 1, 2 and 3 months of age and randomized at 9 months to receive PPV (PCV10/PPV-vaccinated, n = 51; PCV13/PPV-vaccinated, n = 52) or no PPV (PCV10/PPV-naive, n = 57; PCV13/PPV-naive, n = 48). All children received a micro-dose of PPV at 23 months of age to study the capacity to respond to a pneumococcal challenge. PPV vaccination resulted in significantly increased IgG responses (1.4 to 10.5-fold change) at 10 months of age for all PPV-serotypes tested. Both PPV-vaccinated and PPV-naive children responded to the 23-month challenge and post-challenge seroprotection rates (IgG ≥ 0.35 μg/mL) were similar in the two groups (80–100% for 12 of 14 tested vaccine serotypes). These findings show that PPV is immunogenic in 9-month-old children at high risk of pneumococcal infections and does not affect the capacity to produce protective immune responses. Priming with currently available PCVs followed by a PPV booster in later infancy could offer improved protection to young children at high risk of severe pneumococcal infections caused by a broad range of serotypes.
