A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases

Andrew F. Voter; Yupeng Qiu; Ramreddy Tippana; Sua Myong; James L. Keck

doi:10.1038/s41467-018-06751-8

Nature Communications (Oct 2018)

A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases

Andrew F. Voter,
Yupeng Qiu,
Ramreddy Tippana,
Sua Myong,
James L. Keck

Affiliations

Andrew F. Voter: Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health
Yupeng Qiu: Department of Biophysics, Johns Hopkins University
Ramreddy Tippana: Department of Biophysics, Johns Hopkins University
Sua Myong: Department of Biophysics, Johns Hopkins University
James L. Keck: Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health

DOI: https://doi.org/10.1038/s41467-018-06751-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

Read online

How G-quadruplexes (G4s) are resolved by helicases is still a matter of investigation. Here the authors provide mechanistic insight into G4s unwinding by presenting a crystal structure of resolved G4 DNA and the G4 binding domain of RecQ helicase from the bacterium Cronobacter sakazakii.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal