Organic Nanoplatforms for Iodinated Contrast Media in CT Imaging
Peng Zhang,
Xinyu Ma,
Ruiwei Guo,
Zhanpeng Ye,
Han Fu,
Naikuan Fu,
Zhigang Guo,
Jianhua Zhang,
Jing Zhang
Affiliations
Peng Zhang
Department of Cardiology, Tianjin Chest Hospital, Tianjin University, Tianjin 300222, China
Xinyu Ma
Key Laboratory of Systems Bioengineering of the Ministry of Education, Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
Ruiwei Guo
Key Laboratory of Systems Bioengineering of the Ministry of Education, Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
Zhanpeng Ye
Key Laboratory of Systems Bioengineering of the Ministry of Education, Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
Han Fu
Graduate School, Tianjin Medical University, Tianjin 300070, China
Naikuan Fu
Department of Cardiology, Tianjin Chest Hospital, Tianjin University, Tianjin 300222, China
Zhigang Guo
Department of Cardiology, Tianjin Chest Hospital, Tianjin University, Tianjin 300222, China
Jianhua Zhang
Key Laboratory of Systems Bioengineering of the Ministry of Education, Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
Jing Zhang
Department of Cardiology, Tianjin Chest Hospital, Tianjin University, Tianjin 300222, China
X-ray computed tomography (CT) imaging can produce three-dimensional and high-resolution anatomical images without invasion, which is extremely useful for disease diagnosis in the clinic. However, its applications are still severely limited by the intrinsic drawbacks of contrast media (mainly iodinated water-soluble molecules), such as rapid clearance, serious toxicity, inefficient targetability and poor sensitivity. Due to their high biocompatibility, flexibility in preparation and modification and simplicity for drug loading, organic nanoparticles (NPs), including liposomes, nanoemulsions, micelles, polymersomes, dendrimers, polymer conjugates and polymeric particles, have demonstrated tremendous potential for use in the efficient delivery of iodinated contrast media (ICMs). Herein, we comprehensively summarized the strategies and applications of organic NPs, especially polymer-based NPs, for the delivery of ICMs in CT imaging. We mainly focused on the use of polymeric nanoplatforms to prolong circulation time, reduce toxicity and enhance the targetability of ICMs. The emergence of some new technologies, such as theragnostic NPs and multimodal imaging and their clinical translations, are also discussed.
