The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, China
Lidong Gong
Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China
Tianjiao Peng
Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China
Jun Yao
Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China; Corresponding authors.
Zhiqiang Lin
Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Corresponding authors.
Bioresponsive nanosystems are increasingly important in a wide range of applications such as drug delivery, tissue engineering, imaging diagnostics and biosensors. Among these, pH-responsive delivery systems have gained considerable attention because of their ability in response to disease microenvironment and pH-triggered release of therapeutic drugs for therapy. In view of the importance of pH-sensitive nano-delivery systems, this review article highlights four types of pH-responsive modes, the corresponding design strategies, applications and future directions by smart design of pH-sensitive nanosystems for precision imaging or therapy.
