Frontiers in Immunology (Feb 2022)
Insufficient Iron Improves Pristane-Induced Lupus by Promoting Treg Cell Expansion
- Xiaofei Gao,
- Xiaofei Gao,
- Xiaofei Gao,
- Xiaofei Gao,
- Yang Song,
- Yang Song,
- Yang Song,
- Yang Song,
- Shuang Lu,
- Shuang Lu,
- Shuang Lu,
- Shuang Lu,
- Longyuan Hu,
- Longyuan Hu,
- Longyuan Hu,
- Longyuan Hu,
- Meiling Zheng,
- Meiling Zheng,
- Meiling Zheng,
- Meiling Zheng,
- Sujie Jia,
- Sujie Jia,
- Ming Zhao,
- Ming Zhao,
- Ming Zhao,
- Ming Zhao
Affiliations
- Xiaofei Gao
- Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
- Xiaofei Gao
- Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China
- Xiaofei Gao
- Research Unit of Key Technologies of Diagnosis and Treatment for Immune-related Skin Diseases, Chinese Academy of Medical Sciences, Changsha, China
- Xiaofei Gao
- Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province, Changsha, China
- Yang Song
- Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
- Yang Song
- Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China
- Yang Song
- Research Unit of Key Technologies of Diagnosis and Treatment for Immune-related Skin Diseases, Chinese Academy of Medical Sciences, Changsha, China
- Yang Song
- Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province, Changsha, China
- Shuang Lu
- Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
- Shuang Lu
- Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China
- Shuang Lu
- Research Unit of Key Technologies of Diagnosis and Treatment for Immune-related Skin Diseases, Chinese Academy of Medical Sciences, Changsha, China
- Shuang Lu
- Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province, Changsha, China
- Longyuan Hu
- Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
- Longyuan Hu
- Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China
- Longyuan Hu
- Research Unit of Key Technologies of Diagnosis and Treatment for Immune-related Skin Diseases, Chinese Academy of Medical Sciences, Changsha, China
- Longyuan Hu
- Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province, Changsha, China
- Meiling Zheng
- Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
- Meiling Zheng
- Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China
- Meiling Zheng
- Research Unit of Key Technologies of Diagnosis and Treatment for Immune-related Skin Diseases, Chinese Academy of Medical Sciences, Changsha, China
- Meiling Zheng
- Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province, Changsha, China
- Sujie Jia
- Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China
- Sujie Jia
- Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China
- Ming Zhao
- Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
- Ming Zhao
- Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China
- Ming Zhao
- Research Unit of Key Technologies of Diagnosis and Treatment for Immune-related Skin Diseases, Chinese Academy of Medical Sciences, Changsha, China
- Ming Zhao
- Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province, Changsha, China
- DOI
- https://doi.org/10.3389/fimmu.2022.799331
- Journal volume & issue
-
Vol. 13
Abstract
Trace element iron affects T cell biology, but the knowledge about the role of iron in regulating Treg cell expansion is limited. Treg cells play an important role in keeping peripheral T cell tolerance, increasing Treg cell expansion is a promising therapeutic method for SLE. Here we showed that iron deficiency promotes Treg cell expansion by reducing ROS accumulation, improving the disease progression of pristane-induced lupus. Increased oxidative stress inhibits Treg cell differentiation by inducing cell apoptosis. Our data suggest that altering iron metabolism promotes Treg cell expansion by preventing oxidation-induced cell death, which may provide a potential therapeutic strategy for SLE.
Keywords
