Phytoecdysteroids from <i>Serratula coronata</i> L. for Psoriatic Skincare
Anna Kroma,
Mariola Pawlaczyk,
Agnieszka Feliczak-Guzik,
Maria Urbańska,
Dorota Jenerowicz,
Agnieszka Seraszek-Jaros,
Małgorzata Kikowska,
Justyna Gornowicz-Porowska
Affiliations
Anna Kroma
Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, 3 Rokietnicka St., 60-806 Poznań, Poland
Mariola Pawlaczyk
Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, 3 Rokietnicka St., 60-806 Poznań, Poland
Agnieszka Feliczak-Guzik
Department of Chemistry, Adam Mickiewicz University, 8 Uniwersytetu Poznańskiego St., 61-614 Poznań, Poland
Maria Urbańska
Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, 3 Rokietnicka St., 60-806 Poznań, Poland
Dorota Jenerowicz
Department of Dermatology, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-356 Poznań, Poland
Agnieszka Seraszek-Jaros
Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, 4 Rokietnicka St., 60-806 Poznań, Poland
Małgorzata Kikowska
Laboratory of Pharmaceutical Biology and Plant Biotechnology, Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, 3 Rokietnicka St., 60-806 Poznań, Poland
Justyna Gornowicz-Porowska
Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, 3 Rokietnicka St., 60-806 Poznań, Poland
Phytoecdysones from Serratula coronata seem to be promising agents for skincare in patients with psoriasis. The aim of the study was to determine the effects of creams containing the extract of S. coronata on psoriatic lesions. Creams with different formulas were prepared: 0-Lekobaza®, 1-Lekobaza®, S. coronata, 2-Lekobaza®, Salicylic acid, 3-Lekobaza®, S. coronata, Salicylic acid. After examination of skin penetration and biosafety, the designated cream was applied twice daily for 6 weeks on 72 psoriatic plaques located on elbows or knees. The lesions were assessed at baseline and follow-up of 6 weeks. The lesions area was measured, and severity of scaling, erythema, and infiltration was assessed using a 5-point scale (from 0—none to 4—very severe). Skin hydration and structure, pH, transepidermal water loss, erythema, and melanin index were analyzed instrumentally. Creams 1, 2, and 3 significantly reduced the area of psoriatic plaques. Improvement in erythema and infiltration was observed for creams 1 and 3. Creams 1–3 reduced scaling. Our study confirmed a beneficial effect of creams containing S. coronata extract on psoriatic lesions.
