Expression and clinical significance of the securin in colorectal cancer

Abstract

Purpose: Securin is a regulatory protein, which plays a central role in chromosome stability and control of the metaphase-anaphase transition and anaphase onset. Securin blocks separase/extra spindle pole bodies homolog 1 function, preventing the proteolysis of the subsequent dissociation of the chromosome. Securin is expressed at low level in most tissues, but many patient suffering epithelial neoplasms are over-expressed. The aim our study was to evaluate whether securin affects tumorigenesis and prognosis in patients of colorectal cancer. Methods: To clarify the roles of securin in colorectal tumorigenesis, its expression was examined by immunohistochemistry on a tissue microarray with its comparison with clinicopathologic parameters and prognosis survivals of the colorectal carcinomas. Results: Securin was overexpressedin 272 (76.2%) of 357 colorectal carcinomas. Overexpression of securin was correlated with gender (P=0.060), pathologic T stage (P=0.006) and tumor node metastasis stage (P=0.002), but securin overexpression was not correlated with lymphovascular invasions. Securin overexpression was not correlated with 5-year survival rate by Kaplan-Miere survival model. Conclusion: Securin expression was correlated with T stage and TNM (tumor node and metastasis) stage in colorectal cancer. Our study showed a possible role for securin in colorectal tumorigenesis. These findings indicate that securin has a function of tumorigenesis with tumor enlargement, not of lymphovasculogenesis.

Keywords

• carcinogenesis
• chromosomal instability
• colorectal neoplasms
• pituitary tumor-transforming gene protein