Jichu yixue yu linchuang (Apr 2023)

Research progress on the role of HMGB1 signal pathway in bronchial asthma

  • SUN Ying, YANG Zhian, HE Yao, YU Qin

DOI
https://doi.org/10.16352/j.issn.1001-6325.2023.04.0690
Journal volume & issue
Vol. 43, no. 4
pp. 690 – 694

Abstract

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High mobility group box 1 protein (HMGB1), as a ubiquitous nuclear protein, expresses in almost all cells. After activation and release, HMGB1 binds to its receptor and mediates pulmonary inflammatory response. HMGB1 signaling pathway is closely related to the occurrence and development of bronchial asthma. Related targeted drug therapy has been carried out in animal test and in clinical trials.

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