Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis

Abstract

The OBJECTIVE was to assess the effectiveness of the developed method for treating DVT with fibrinolytic agent injection via a catheter with multiple openings along the length of entire thrombus.METHODS AND MATERIALS. The analysis of treatment efficacy of 40 patients with late total and subtotal deep vein thrombosis was carried out. The patients were divided into two statistically valid groups. The first group of patients weretreated using regional thrombolysis by injection of Urokinase into the popliteal vein. The second group had fibrinolytic agent injection via a catheter with multiple openings passed along the entire length of thrombosed venous segment. Patients were given Rivaroxaban before, during, and after the therapy continuously for 6 months.RESULTS. After 1 year in the second group, compared to the first group, the excellent and good results were higher by 10 % and 5 % respectively. Satisfactory and unsatisfactory results decreased by 10 and 5 % respectively. While using background Rivaroxaban, the thromboembolic complications were not registered. Hemorrhagic complications were found in 10 % of both group patients with equal rate.CONCLUSION. Injection of a fibrinolytic agent via a catheter with multiple openings along the length of entire thrombus is efficient and pathogenetically substantiated.

Keywords

• total and subtotal thrombosis
• advanced time
• deep veins
• lower extremities
• regional urokinase thrombolysis
• rivaroxaban