Clinical significance of determining neutrophil extracellular traps in women with oncogynecological neoplasms

Abstract

The formation of neutrophil extracellular traps (NETs), described first in 2004 as a previously unknown neutrophil strategy for combating microbes, has been attracting a growing interest in research community. NETs play a key role in inflammation and infection exploiting effector functions such as degranulation, phagocytosis as well as production of reactive oxygen species (ROS). NETs play a crucial role in defense against systemic infections. Additionally NETs involved in inflammation, and in the pathogenesis of non-infectious diseases, such as autoimmune diseases and cancer.

Keywords

• neutrophil extracellular traps
• nets
• netosis
• myeloperoxidase
• citrullinated histone h3
• cancer
• oncological diseases