Pregnancy and survival-related outcomes of uveal melanoma treated with brachytherapy in women of reproductive age

Hao-Tian Wu; Li Dong; Rui-Heng Zhang; Wen-Da Zhou; He-Yan Li; Wen-Bin Wei; Yue-Ming Liu

doi:10.1186/s12886-024-03681-6

BMC Ophthalmology (Sep 2024)

Pregnancy and survival-related outcomes of uveal melanoma treated with brachytherapy in women of reproductive age

Hao-Tian Wu,
Li Dong,
Rui-Heng Zhang,
Wen-Da Zhou,
He-Yan Li,
Wen-Bin Wei,
Yue-Ming Liu

Affiliations

Hao-Tian Wu: Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Beijing Tongren Eye Center, Capital Medical University, 1 Dong Jiao Min Lane,
Li Dong: Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Beijing Tongren Eye Center, Capital Medical University, 1 Dong Jiao Min Lane,
Rui-Heng Zhang: Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Beijing Tongren Eye Center, Capital Medical University, 1 Dong Jiao Min Lane,
Wen-Da Zhou: Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Beijing Tongren Eye Center, Capital Medical University, 1 Dong Jiao Min Lane,
He-Yan Li: Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Beijing Tongren Eye Center, Capital Medical University, 1 Dong Jiao Min Lane,
Wen-Bin Wei: Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Beijing Tongren Eye Center, Capital Medical University, 1 Dong Jiao Min Lane,
Yue-Ming Liu: Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Beijing Tongren Eye Center, Capital Medical University, 1 Dong Jiao Min Lane,

DOI: https://doi.org/10.1186/s12886-024-03681-6
Journal volume & issue: Vol. 24, no. 1
pp. 1 – 7

Abstract

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Abstract Background To examine if pregnancy affects the prognosis of uveal melanoma (UM) patients undergoing plaque brachytherapy (PBT) and to assess if PBT has any subsequent impact on pregnancy outcomes. Methods A retrospective, single-center study was carried out at Beijing Tongren Hospital, focusing on women of childbearing age diagnosed with UM and treated with iodine-125 plaque brachytherapy. Both the outcomes of pregnancies and the health status of the fetuses were monitored. Survival analyses were conducted using the Kaplan-Meier method, with endpoints being metastasis and death. Results A total of 13 patients who had full-term pregnancies and 96 non-pregnant women matched by age and tumor size were included. The mean follow-up time was 67.0 ± 27.7 months (median:66.0 months, range:21.0 to 116.0 months). In the pregnant group, two patients developed metastases, one of whom died shortly after delivery; local recurrence of UM occurred in 2 patients after or during delivery, and 2 other patients developed secondary glaucoma due to radiation retinopathy. None of the other pregnant patients reported any signs of disease progression. In the control group, 18 metastasis cases including 12 deaths were documented. Pregnant patients and matched control subjects showed no statistical difference in both Metastasis-free survival (hazard ratio (HR): 0.66, 95% confidence interval (CI): 0.15–2.86; P = 0.576) and overall survival (HR: 0.48, 95% CI: 0.06–3.66; P = 0.464). All pregnant patients carried the pregnancy to term and delivered healthy children with no report of placental or infant metastases to date. Conclusion Pregnancy does not appear to negatively impact the prognosis of UM patients undergoing PBT. PBT showed no observable detriment to maternal fertility and exhibited no teratogenic effects on the fetus. However, the long-term implications of PBT on pregnancy remain uncertain, necessitating additional, prolonged follow-up studies.

Published in BMC Ophthalmology

ISSN: 1471-2415 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Ophthalmology
Website: http://bmcophthalmol.biomedcentral.com

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