Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice

Affiliations

Ying Zhao: Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University
Wusheng Zhu: Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University
Ting Wan: Department of Neurology, Xijing Hospital, Air Force Medical University
Xiaohao Zhang: Department of Neurology, Nanjing First Hospital, Nanjing Medical University
Yunzi Li: Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University
Zhenqian Huang: Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University
Pengfei Xu: Stroke Center & Department of Neurology, The Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Kangmo Huang: Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University
Ruidong Ye: Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University
Yi Xie: Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University
Xinfeng Liu: Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University

Abstract

OPC-vascular coupling contributes to myelin maintenance. Here the authors show Cav-1 stabilizes interactions and mediates OPC maturation in ischemia.