Prevalence of Celiac Disease and Helicobacter Pylori in Patients Referred to Endoscopy Section of Taleghani Hospital

Abstract

Introduction: According to previous studies celiac disease(CD) is frequently associated with chronic gastritis. The aim of this study was to assess the prevalence of CD and Helicobacter pylori in patients with dyspepsia. Methods: 325 patients were studied from April 2008 to April 2009 who underwent endoscopic procedures for dyspepsia. Gastric antrum, duodenal biopsies, serology with tissue Transglutaminase Antibodies(tTGA) and total IgA were performed for detection of H. pylori and CD. Results: Out of 325 patients 312(96%) had a positive H. pylori. Heart burn and bloating were the most prevalent symptoms in this study. Twenty one of 25 patients with positive histology for CD who had gastric biopsies were positive for H. pylori(84%). Duodenal biopsy specimens results have shown normal histology in 213(65.5%), hyperplastic polyps in 1(0.4%), duodenitis in 79(24.3%) and abnormality in small bowel (Marsh I-IIIc) in 25(10%). In term of the serological analysis, 9 of 26 tTGA positive patients had abnormal histology (Marsh I-IIIc)(2.7%). Conclusion: Similar to previous reports, we found a high prevalence of H. pylori infection and celiac disease in dyspeptic patients. Therefore, further studies for screening occult CD in dyspeptic patients is seems necessary.

Keywords

• Celiac Disease
• Helicobacter Pylori
• Gastritis