ANALYSIS OF EARLY COMPLICATIONS AFTER USING PERMACOL BIOIMPLANT IN COMBINATION WITH SELECTIVE ADMINISTRATION OF THE NICERGOLIN IN CASE OF INTESTINAL FISTULAS

Abstract

Introduction. Intestinal fistulas to date remain one of the unresolved surgical problems. If patients with low intestinal fistulas are treated roughly the same way by the majority of authors, then the most effective treatment of intestinal fistula of high localization remains controversial. In this context, the objective of the work was to improve the treatment of patients with unformed duodenal and high enteric fistulas by local administration of collagen coating with selective angiotropic effect.Materials and methods. The work involved open prospective randomized study including 109 patients admitted in purulent surgery Department of the Republican State Clinical Hospital named after G.G. Kuvatov (city of Ufa) for surgical treatment in the period 2000-2016. The main criterion to include patients in the study was the presence of duodenal and/or other enteric fistulas. All patients were randomly divided into two main groups: group of traditional therapy (68 patients), where, sealing of intestinal fistula was followed by standard pharmacological therapy; the study group (41 patients), where the sutures on intestine were strengthened with collagen with subsequent selective administration of angioprotectors and laser antibiotic therapy.Results. The findings show that the use of originally developed regimen leads to decreased suture failure from 39.5 to 17.0% and lethality from 37.5 to 19.5%. Conclusion. Local application of collagen in combination with selective lengthy administration of angioprotectors allows reducing the frequency of early postoperative complications and thereby improve patients’ health outcomes with unformed duodenal and high enteric fistulas.

Keywords

• свищ кишечника
• двенадцатиперстной кишки болезни
• тонкая кишка
• послеоперационные осложнения
• коллаген
• ницерголин