Anti-Inflammatory and Antithrombotic Potential of Metal-Based Complexes and Porphyrins

Alexandros Tsoupras; Sofia Pafli; Charilaos Stylianoudakis; Kalliopi Ladomenou; Constantinos A. Demopoulos; Athanassios Philippopoulos

doi:10.3390/compounds4020023

Compounds (Jun 2024)

Anti-Inflammatory and Antithrombotic Potential of Metal-Based Complexes and Porphyrins

Alexandros Tsoupras,
Sofia Pafli,
Charilaos Stylianoudakis,
Kalliopi Ladomenou,
Constantinos A. Demopoulos,
Athanassios Philippopoulos

Affiliations

Alexandros Tsoupras: Hephaestus Laboratory, Department of Chemistry, School of Science, Democritus University of Thrace, Kavala University Campus, 65404 Kavala, Greece
Sofia Pafli: Hephaestus Laboratory, Department of Chemistry, School of Science, Democritus University of Thrace, Kavala University Campus, 65404 Kavala, Greece
Charilaos Stylianoudakis: Hephaestus Laboratory, Department of Chemistry, School of Science, Democritus University of Thrace, Kavala University Campus, 65404 Kavala, Greece
Kalliopi Ladomenou: Hephaestus Laboratory, Department of Chemistry, School of Science, Democritus University of Thrace, Kavala University Campus, 65404 Kavala, Greece
Constantinos A. Demopoulos: Laboratory of Biochemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Athanassios Philippopoulos: Laboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece

DOI: https://doi.org/10.3390/compounds4020023
Journal volume & issue: Vol. 4, no. 2
pp. 376 – 400

Abstract

Read online

Inflammation and thrombosis are implicated in several chronic disorders. Recent studies have outlined the way in which several compounds can offer protection against inflammation. Within this comprehensive review the so-far reported anti-inflammatory health-promoting effects of several metal-based complexes, both in vitro and in vivo, are thoroughly presented. These metal-based compounds usually interfere with various biochemical processes associated with the inflammatory response and thrombus formation and become capable of inhibiting these biochemical pathways with proposed health benefits. Emphasis is given to the multifaceted actions of metal-based complexes that have exhibited potent anti-inflammatory and antithrombotic activities against the inflammatory mediator, platelet-activating factor (PAF), and its thrombo-inflammatory signaling, as well as on their anti-platelet and antitumor health promoting properties. Furthermore, the enhancement of the anti-inflammatory potency of well-established bioactive compounds by their incorporation as ligands in several metal-based complexes is discussed. Metal-based complexes bearing natural anti-inflammatory bioactives are also outlined. Characteristic examples of both free and metal-based porphyrins are explored. These compounds are recognized to have anti-inflammatory and antithrombotic assets, in addition to other pleiotropic advantages including antibacterial or anticancer actions. Additionally, applications of metal complexes in various models of inflammatory and thrombotic complications are demonstrated. The combined results of this study show that further research is required towards the preparation of several metal-based complexes with improved pharmacological profiles. Finally, restrictions on the application of these metal-based compounds are also covered, along with their prospects for the future and the need for additional study in order to improve their efficacy and safety.

Published in Compounds

ISSN: 2673-6918 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Physics; Science: Chemistry: Physical and theoretical chemistry
Website: https://www.mdpi.com/journal/compounds

About the journal

Abstract

Keywords