Infection and Drug Resistance (Nov 2020)
Oral Infection Caused by Non-O1/Non-O139 Vibrio cholerae in a Patient with Esophageal Cancer Undergoing Esophagectomy and Chemoradiotherapy: A Case Report
Abstract
Hongxiang Xie,1,2,* Yuanyuan Wu,3,* Cuiping Liu,4 Jianzhuang Guo,2 Jianping Ma,2 Xiaofeng Li,2 Xiaojun Sun2 1Department of Clinical Laboratory, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Mainland China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Shandong First Medical University, Jinan, Mainland China; 3Department of Shungen Conservative and Endodontic Dentistry, Jinan Stomatology Hospital, Jinan, Mainland China; 4Department of General Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, Mainland China*These authors contributed equally to this workCorrespondence: Xiaojun Sun Department of Clinical LaboratoryThe First Affiliated Hospital of Shandong First Medical University, 16766 Jingshi Road, Jinan, Shandong 250014, Mainland ChinaTel +86-571-87666666Fax +86-571-85335800Email [email protected]: Non-O1/non-O139 Vibrio cholerae (NOVC) are increasingly being recognized as causes of sporadic cases of gastroenteritis and extra-intestinal invasive infections, such as bacteremia as well as skin and wound infections in immunosuppressed hosts. However, oral infections caused by these microorganisms have rarely been reported. We present a case of oral infection caused by NOVC in a patient undergoing chemoradiotherapy after esophagectomy for esophageal cancer. The patient recovered well after antibiotic treatment. The isolate from the patient was screened for phenotypic and genetic characteristics with reference to their major virulence genes. Our report provides supporting evidence for oral infection due to NOVC in a patient with esophageal cancer and suggests that some putative accessory virulence factors may be crucial in the pathogenicity of this strain. To the best of our knowledge, this is the first documented case of oral infection due to NOVC.Keywords: non-O1/non-O139 Vibrio cholerae, oral infection, esophageal cancer, chemoradiotherapy
