Evaluation of genotoxic effects of c60 fullerene-γ-fe2o3 and multi-wall carbon nanotubes-γ-fe2o3 nanoparticles

Abstract

The use of magnetic nanoparticles in nanomedicine applications has increased significantly in recent years. Genotoxic evaluation of the nanomaterials used for this purpose is therefore very important. In our study, the genotoxic effect of C60 fullerene-γ-Fe2O3 and multi-wall carbon nanotubes-γ-Fe2O3 magnetic nanoparticles over a wide concentration range (0.1, 1.0, 5.0, 10.0, 25.0, 50.0, and 100.0 μg/plate) was investigated using the Bacterial Reverse Mutation Test. These magnetic nanoparticles did not cause genetic damage to Salmonella typhimurium TA100 and TA98 in the presence and absence of metabolic activation. Due to the rapid increase in the presence of nanoparticles in our daily lives, mutagenicity and toxicity data related to nanoparticles are quite valuable. For this reason, in vivo and in vitro studies that allow for effective evaluation of these compounds is of the utmost importance.

Keywords

• genotoxicity
• nanotoxicity
• multi-wall carbon nanotubes-γ-fe2o3
• c60 fullerene-γ-fe2o3
• salmonella/microsome mutagenicity assay