Methyl 5-(4-hydroxy-3-methoxyphenyl)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

Abstract

In the title compound, C24H22N2O6S, a pyrimidine ring substituted with 4-hydroxy-3-methoxyphenyl is fused with a thiazole ring. The 4-hydroxy-3-methoxyphenyl group is positioned axially to the pyrimidine ring, making a dihedral angle 85.36 (7)°. The pyrimidine ring adopts a twist boat conformation. In the crystal, O—H...N interactions result in a chain running along the b axis. The carbonyl O atom bonded to the thiazole ring is involved in two C—H...O hydrogen-bond interactions forming centrosymmetric dimers; the ten- and six-membered rings resulting from these interactions have R22(10) and R12(6) motifs, respectively.