Biased Immunoglobulin Genes Rearrangement in Mantle Cell Lymphoma: Hints to Identify the Normal B-cell Counterpart

Abstract

Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma, originating from naı ¨ve B-cells. The blastoid MCL tumors often show complex cytogenetic aberrations. In this review, we summarized the data available on immunoglobulin heavy-chain (IgH) genes rearrangement for their importance in suggesting the MCL normal counterpart B-cell. Some new data suggesting an antigen selection process were also presented in this review.

Keywords

• mantle cell lymphoma
• immunoglobulin genes
• somatic hypermutation