Factors Associated with Recurrence of Intracranial Meningiomas After Surgical Resection: A Retrospective Single-Center Study

Abstract

Summary: Background: Meningioma is one of the most common primary brain neoplasms with poor outcomes. The present study was aimed to determine clinical and surgical characteristics of intracranial meningiomas associated with tumor recurrence and complications. Methods: A total of 138 patients undergoing surgical resection of intracranial meningiomas between Jan 2003 and Dec 2014 were included and followed for the period of at least 12 months. The demographic and clinical characteristics possibly associated with tumor recurrence were assessed, including age, gender, clinical symptoms, pathology data, tumor parameters, preoperative and postoperative Karnofsky Performance Scale (KPS), complications and recurrence rate. Results: One hundred and twenty one lesions were benign (classified as Grade I) and 17 were atypical/malignant (classified as Grade II/III). The patients were of a mean age of 60.5 years and a mean follow-up duration of 36.8 months (range, 16.3–62.9 months). The 1, 3, 5-year recurrence/tumor enlargement rates were 3.4%, 7.2%, and 15.7%, respectively. In multivariate analysis, symptoms of disturbance of consciousness and palpable cranial mass were associated with increased recurrence/tumor enlargement. In addition, patients with Simpson grade IV were more likely to have recurrence/tumor enlargement. Conclusion: The pattern of intracranial meningioma in this series is typical to other studies. Presenting symptoms is suggested to be predictive of recurrence. Keywords: intracranial meningiomas, recurrence, risk factor