Dermatology Reports (Jul 2022)

A case of sweat-gland carcinoma with neuroendocrine differentiation (SCAND)

  • Shigeru Koizumi,
  • Yaei Togawa,
  • Inozume Takashi,
  • Michiyo Nakano

DOI
https://doi.org/10.4081/dr.2022.9513

Abstract

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A 73-year-old Japanese male patient presented to our hospital with a red nodule arising from the lower abdomen to the base of the penis. After the biopsy, the tumor was diagnosed as sweat gland carcinoma with neuroendocrine differentiation (SCAND) with bilateral inguinal lymph node metastasis. SCAND is newly proposed entity and very rare disease in 2022. Although SCAND often showed stromal mucin deposition, a tumor mass floating in abundant mucus, which was never reported before in SCAND, was observed histopathologically in our case. Primary cutaneous mucinous carcinoma (PCMC) with neuroendocrine differentiation was considered as a differential diagnosis. However, the feature only occupied a small portion of the tumor (<10%), and PCMC predominantly originated in the head and neck region. Therefore, we considered PCMC could be ruled out. Consequently, while SACND and PCMC sometimes share histologic similarities, their differentiation is important because PCMC rarely metastasizes while SCAND often does.

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