Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses

Abstract

IL-27 is one of a number of cytokines that can induce antitumour CD8+ T cell responses. Here the authors show that TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.