Recent Developments in Photoinduced Decarboxylative Acylation of α-Keto Acids
Shuaiqi Lu,
Yilong Xiang,
Jingfu Chen,
Chao Shu
Affiliations
Shuaiqi Lu
State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, CCNU-uOttawa Joint Research Centre, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan 430079, China
Yilong Xiang
State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, CCNU-uOttawa Joint Research Centre, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan 430079, China
Jingfu Chen
China National Standard Pharmaceutical Corporation Limited, Huangshi 435002, China
Chao Shu
State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, CCNU-uOttawa Joint Research Centre, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan 430079, China
Ketones are ubiquitous patterns found in various biological molecules and natural products. In recent years, a number of acylation methods have been developed based on the use of α-oxocarboxylic acids as acyl-transfer reagents, with particular emphasis on the photoinduced decarboxylative acylation of α-keto acids. This review focuses on the latest advancements in acylation methodologies through the decarboxylation of α-keto acids over the past several years, highlighting their product diversity, selectivity, and applicability. Where possible, the mechanistic rationale is presented, providing a positive outlook for the promising future of this field.
