p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice

Pablo Bora; Lenka Gahurova; Tomáš Mašek; Andrea Hauserova; David Potěšil; Denisa Jansova; Andrej Susor; Zbyněk Zdráhal; Anna Ajduk; Martin Pospíšek; Alexander W. Bruce

doi:10.1038/s42003-021-02290-z

Communications Biology (Jun 2021)

p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice

Pablo Bora,
Lenka Gahurova,
Tomáš Mašek,
Andrea Hauserova,
David Potěšil,
Denisa Jansova,
Andrej Susor,
Zbyněk Zdráhal,
Anna Ajduk,
Martin Pospíšek,
Alexander W. Bruce

Affiliations

Pablo Bora: Laboratory of Early Mammalian Developmental Biology (LEMDB), Department of Molecular Biology & Genetics, Faculty of Science, University of South Bohemia
Lenka Gahurova: Laboratory of Early Mammalian Developmental Biology (LEMDB), Department of Molecular Biology & Genetics, Faculty of Science, University of South Bohemia
Tomáš Mašek: Laboratory of RNA Biochemistry, Department of Genetics and Microbiology, Faculty of Science, Charles University
Andrea Hauserova: Laboratory of Early Mammalian Developmental Biology (LEMDB), Department of Molecular Biology & Genetics, Faculty of Science, University of South Bohemia
David Potěšil: Central European Institute of Technology, Masaryk University
Denisa Jansova: Laboratory of Biochemistry and Molecular Biology of Germ Cells, Institute of Animal Physiology and Genetics
Andrej Susor: Laboratory of Biochemistry and Molecular Biology of Germ Cells, Institute of Animal Physiology and Genetics
Zbyněk Zdráhal: Central European Institute of Technology, Masaryk University
Anna Ajduk: Department of Embryology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw
Martin Pospíšek: Laboratory of RNA Biochemistry, Department of Genetics and Microbiology, Faculty of Science, Charles University
Alexander W. Bruce: Laboratory of Early Mammalian Developmental Biology (LEMDB), Department of Molecular Biology & Genetics, Faculty of Science, University of South Bohemia

DOI: https://doi.org/10.1038/s42003-021-02290-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 19

Abstract

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Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a permissive translational environment during mouse blastocyst primitive endoderm differentiation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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