Nature Communications (Sep 2017)

Misalignment with the external light environment drives metabolic and cardiac dysfunction

  • Alexander C. West,
  • Laura Smith,
  • David W. Ray,
  • Andrew S. I. Loudon,
  • Timothy M. Brown,
  • David A. Bechtold

DOI
https://doi.org/10.1038/s41467-017-00462-2
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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The misalignment between internal circadian rhythm and the day-night cycle can be caused by genetic, behavioural and environmental factors, and may have a profound impact on human physiology. Here West et al. show that desynchrony between the internal clock and the external environment alter metabolic parameters and cardiac function in mice.