Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells

Weizhen Jia; Lingyu Kong; Hiroyasu Kidoya; Hisamichi Naito; Fumitaka Muramatsu; Yumiko Hayashi; Han-Yun Hsieh; Daishi Yamakawa; Daniel K. Hsu; Fu-Tong Liu; Nobuyuki Takakura

doi:10.1038/s41467-021-22346-2

Nature Communications (Apr 2021)

Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells

Weizhen Jia,
Lingyu Kong,
Hiroyasu Kidoya,
Hisamichi Naito,
Fumitaka Muramatsu,
Yumiko Hayashi,
Han-Yun Hsieh,
Daishi Yamakawa,
Daniel K. Hsu,
Fu-Tong Liu,
Nobuyuki Takakura

Affiliations

Weizhen Jia: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita
Lingyu Kong: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital
Hiroyasu Kidoya: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita
Hisamichi Naito: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita
Fumitaka Muramatsu: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita
Yumiko Hayashi: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita
Han-Yun Hsieh: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita
Daishi Yamakawa: Department of Physiology, Mie University Graduate School of Medicine
Daniel K. Hsu: Department of Dermatology, School of Medicine, University of California-Davis
Fu-Tong Liu: Department of Dermatology, School of Medicine, University of California-Davis
Nobuyuki Takakura: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita

DOI: https://doi.org/10.1038/s41467-021-22346-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary and sufficient for LT-HSC quiescence through regulation of p21.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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